Epstein–Barr virus (Herpesviridae: <i>Lymphocryptovirus</i>) types 1 and 2 and other viral markers in patients with nasopharyngeal carcinoma in two geographically and ethnically distinct regions of Russia

Introduction. The discovery of two types EpsteinBarr virus (EBV) (EBV-1 and EBV-2) that have different biological properties stimulated the search for neoplasms associated with each type virus.
 aim work is to study nature association nasopharyngeal cancer (NPC) EBV-1 EBV-2, serological activity viral concentration EBV DNA in blood plasma gender, age ethnic groups NPC patients represent geographically climatically regions Russia,.
 Materials methods. In other non- tumors oral cavity (OTOCEBV) from North Caucasian (NCFD) Central (CFD) Federal Districts Russia, were determined using respectively nested real time PCR; titers IgG IgA antibodies capsid antigen (VCA) measured indirect immunofluorescence assay.
 Results. samples testing showed OTOCEBV infected both approximately equal proportions. one only, or respectively, no statistically significant differences found between geometric mean values anti-EBV antibody concentrations plasma. distribution was not affected by either patient gender ethnogeographic origin. difference only groups: EBV-2 dominated up 60 years, prevalent over years.
 Conclusion. lack predominance are representatives regions, suggests none these factors play an important role carcinogenesis. Evidently, EBV, if necessary conditions arise, able exhibit its oncogenic potential initiate tumor development.